Solid Lipid Nanoparticle


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Solid lipid nanoparticles (SLN) form an alternative carrier system to the traditional carrier options, such as the liposomes. Generally, SLN have diameters between 50-1000nm. Because their size-dependent properties, they are promising agents in developing controlled and site specific drug release therapies.



Figure 1. Structure of a solid lipid nanoparticle

Assembly of Solid Lipid Nanoparticles

  • Solid lipid nanoparticles are assembled with NanoAssemblr in the Li Lab.
  • Lipids and drugs are dissolved in the organic phase, while buffer is injected through the aqueous phase.
  • Alteration of flow rate and flow ratio can vary the property of the resulting nanoparticles.





Figure 2. NanoAssemblr (up) and an example of NanoAssemblr set up using 5% glucose buffer as the aqueous phase (down)



  • Sustained ophthalmic formulation
  • β-amyloid imaging





Figure 3. Assembly of solid lipid nanoparticles with NanoAssemblr has shown to increase the solubility of water-insoluble curcumin to enhance the delivery of the drug